Melatonin Source
As we have been describing, melatonin is a compound synthesized endogenously when exposed to darkness, or at least a lack of certain wavelengths of light, for a period of time. This endogenous compound has a variety of benefits, for instance, modulating thyroid hormone levels and thus mitochondrial respiration on a systemic level. As Dr. Pierpaoli has described in depth in his books, published studies, and interviews, there may be a benefit to supplementing melatonin that isn’t derived from simply avoiding blue light (and some other wavelengths, too) at night. Supplementing melatonin may simultaneously increase and maintain the “melatonin peak” that occurs during the night, while also giving the pineal gland a break, allowing it to more efficiently do its job as time goes on.
Anyhow, there are a variety of sources of melatonin as a supplement, and they’re undoubtedly not created equal. Many supplements are loaded with excipients that not only interfere with the compounds effects, but may cause allergic-like effects and inflammatory responses. Furthermore, there may be no way to change the dose, and apparently the lowest doses work best and actually produce the true results. If you get capsules that contain 3mg, it’s almost impossible to cut that down into, say, 0.3mg.
Fortunately, there is a product that can not only be broken up for smaller doses, but that comes packed with melatonin co-factors such as zinc and selenium. The only product that has all of this going for it is Dr. Pierpaoli’s “melatonin zinc selenium”, or what we’ve been calling MZS. It works quite well for most, and can be taken in larger or smaller doses. There are also melatonin patches that we have yet to discuss, but some people have gotten good results with those, too. Another good thing to add to these supplemnts would be blue light blockers. These will enhance your own endogenous synthesis of melatonin. Overall, the addition of melatonin (and maybe co-factors) at a low dose (to derive the most effects), blue light blockers, and red light at night should have a person feeling much, much better.
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